在体外生物活性,机械和细胞相互作用加化加硫酸盐-酸酸复合物骨水泥
Pharatree Jaita1,2,3, Chamnan Randorn4, Anucha Watcharapasorn1,3
1Department of Physics and Materials Science, Faculty of Science, Chiang Mai University Chiang Mai 50200 Thailand.
RSC advances
|November 7, 2024
概括
将化 (NaCl) 添加到硫酸-酸酸 (CaS-HAP) 骨头水泥中,可以提高其生物活性和细胞相容性. 优化的 (0.70CaS-0.30HAP) /2.5NaCl复合物显示出优异的无酸盐形成和生物医学用途的细胞活力.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 材料化学 材料化学
背景情况:
- 硫酸-酸 (CaS-HAP) 复合骨在骨科应用中被广泛使用.
- 优化骨质水泥特性,如定位时间,可注射性和生物活性,对于临床成功至关重要.
研究的目的:
- 为了研究化 (NaCl) 添加对CaS-HAP复合骨的特性的影响.
- 为了评估潜在的生物医学应用中NaCl修饰骨的生物活性,机械强度和细胞相容性.
主要方法:
- 合成 (0.70CaS-0.30HAP) /xNaCl复合骨,使用不同的NaCl重量% (0,1.5,2.5).
- 特性包括设置时间,可注射性,冲洗性,相位分析 (X射线衍射),物理性质,吸水性,微观结构分析,机械测试 (压力和屈曲强度,Young的模量),体外无氧化物形成和体外细胞毒性测试.
主要成果:
- 增加NaCl含量减少了初始设置时间 (至3.18分钟),增加了水的吸收和平均颗粒大小.
- 机械性能随着NaCl的增加而略有下降,由于孔隙性增加,但导致了卓越的 in vitro 酸盐形成能力.
- 该x=2.5样本表现出优越的生物活性,在模拟体液 (SBF) 中具有最高的阿帕矿化,以及超过94.12%的细胞活力,表明良好的细胞相容性.
结论:
- 将NaCl添加到CaS-HAP复合骨质水泥中会影响其定时间,物理性质和生物活性.
- (0.70CaS-0.30HAP) /2.5NaCl复合骨质水泥显示有希望的注射性,生物活性和细胞相容性,使其成为生物医学应用的潜在候选者.
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