65岁及以上重症患者的宿主反应:一项前性研究
Hui Lian1, Guangjian Wang2, Hongmin Zhang2
1Department of Health Care, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Clinical interventions in aging
|November 7, 2024
概括
衰老显著改变了严重疾病的老年患者的宿主反应. 老年人较低的免疫生物标志物与较高的死亡率相关,但预测模型显示出预后效用.
科学领域:
- 老年医学 老年医学
- 关键护理医学 关键护理医学
- 免疫学 免疫学 免疫学
背景情况:
- 主体反应在严重疾病中至关重要,特别是在老龄化人口中.
- 了解宿主反应中与年龄相关的变化有助于ICU诊断和治疗.
- 全球老龄化需要对老年人重症监护的研究.
研究的目的:
- 调查衰老对严重病情的老年患者宿主反应的影响.
- 为了确定与死亡率和停留时间相关的宿主反应生物标志物.
- 开发老年重症监护室 (GICU) 患者死亡率的预测模型.
主要方法:
- 追溯分析了1204名65岁以上的患者,这些患者被录入GICU.
- 从电子医疗记录中提取人口,临床和药物数据.
- 一般化添加混合模型和名录分析用于死亡率预测.
主要成果:
- 85岁以上的患者表现出较低的宿主反应生物标志物和较高的死亡率.
- 白细胞计数,LDH,IL-10和TNF-α与死亡率相关.
- 较高的血小板与淋巴细胞比率和淋巴细胞数量是显著因素.
结论:
- 衰老显著影响严重病情严重的老年患者的宿主反应.
- 使用炎症,免疫和凝血标记物的预测模型具有预后价值.
- 调查结果有助于评估ICU中的危急病情的老年患者.
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