在纤维肌痛综合征中,蛋白转化酶子提利辛/克辛9型和阿佩林在纤维肌痛综合征中
Nevsun Pihtili Taş1, Rabia Aydogan Baykara2, Ayhan Kamanli3
1Department of Physical Medicine and Rehabilitation, Health Sciences University, Elazığ Fethi Sekin City Health Application and Research Center, Elazığ, Türkiye.
Archives of rheumatology
|November 7, 2024
概括
在纤维肌痛综合征 (FS) 患者中,PCSK9和阿佩林水平的升高显著更高,这表明它们作为FS和相关症状的预测生物标志物的潜力.
科学领域:
- 生物化学 生物化学
- 医学研究 医学研究
- 临床诊断 临床诊断 临床诊断
背景情况:
- 纤维肌痛综合征 (FS) 是一种复杂的慢性疼痛障碍,病因不明.
- 蛋白转化酶亚素/素9型 (PCSK9) 和阿佩林是具有在各种生理过程中的作用的.
- 研究新的生物标志物对于理解和诊断FS至关重要.
研究的目的:
- 检查PCSK9和apelin在纤维肌痛综合征的发展中的潜在参与.
- 评估PCSK9和阿佩林水平之间的相关性以及FS相关的临床评估.
- 确定PCSK9和apelin作为FS的生物标志物的诊断效用.
主要方法:
- 一项回顾性研究,涉及58名女性FS患者和30名健康对照.
- 使用已确定的实验室方法测量PCSK9和阿佩林的血清水平.
- 统计分析以比较群体之间的水平,并与临床测量相关联.
主要成果:
- 与对照组相比,FS患者的PCSK9 (p<0.001) 和阿佩林 (p<0.001) 水平显著更高.
- 在PCSK9/apelin和FS影响问卷,症状严重程度量表,睡眠质量和抑郁症/焦虑症得分之间发现了积极的相关性.
- PCSK9显示FS的高预测值 (AUC=0.920),最佳切线为110.0 ng/mL.
结论:
- PCSK9可能有助于FS病因和氧化应激.
- 升高的阿佩林可能是对氧化应激的补偿反应,可能导致过敏症.
- 无论是PCSK9还是apelin,都显示出作为纤维肌痛综合征的预测标记物的前景.
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