低强度冲击波治疗勃起功能障碍是否是一种持久的治疗选择? - 随机模拟受控试验的长期结果
Moritz Lange1, David Charles1, Aisha Kazeem1
1Department of Urology, University of Virginia, Charlottesville, VA, USA.
Translational andrology and urology
|November 7, 2024
概括
低强度冲击波疗法 (LiSWT) 在患有ED的男性中提供长达两年的持续性勃起功能改善. 虽然有效,但治疗效益似乎在治疗后的第二年和第三年之间减少.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 再生医学是一种再生医学.
- 非侵入性疗法 非侵入性疗法
背景情况:
- 低强度冲击波疗法 (LiSWT) 是对勃起功能障碍 (ED) 的一个有前途的非侵入性治疗方法.
- 以前的研究表明LiSWT的有效性,但长期耐用性数据有限.
- 这项研究评估了LiSWT对ED男性的长期结果.
研究的目的:
- 评估LiSWT后勃起功能改善的长期持久性.
- 为了评估勃起功能得分的变化,治疗后长达36个月.
- 为了确定患者对治疗ED的LiSWT的满意度.
主要方法:
- 一项随机对照试验 (RCT) 涉及30名ED患者.
- 患者接受了LiSWT或假药治疗,假药组的交叉治疗.
- 治疗包括每周两次进行3周的会议,使用特定的冲击波装置.
- 主要结局包括男性性健康库存 (SHIM) 和勃起硬度得分 (EHS) 的变化.
- 使用勃起功能障碍治疗满意度清单 (EDITS) 指数来衡量患者满意度.
主要成果:
- 在治疗后12个月和24个月观察到SHIM和EHS得分的显著改善 (P<0.001).
- SHIM分数在12个月和24个月持续增加,在36个月略有下降 (P=0.31).
- 在12个月和24个月时,EHS分数也显著改善,在36个月时没有显著下降 (P=0.10).
- 中位数EDITS得分表明患者满意度中等.
- 在研究期间没有报告任何不良事件.
结论:
- LiSWT在不同群体的ED男性中显示了长期持续改善勃起功能.
- 治疗效果的峰值在1年后被观察到,持久的效益持续长达2年.
- 在治疗后2到3年之间可能会出现治疗效果的下降.
- 需要对更大的队列进行进一步的研究,以证实这些长期发现.
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