维生素C摄入量和骨关节炎:NHANES 2003-2018和门德尔随机化研究的发现
Hongjie Zhang1,2,3, Xuan Jiang3,4, Lei Bai2
1Dehong People's Hospital, Kunming Medical University Affiliated Dehong Hospital, Mangshi, China.
Frontiers in nutrition
|November 7, 2024
概括
这项研究发现,维生素C摄入量与骨关节炎 (OA) 风险之间没有联系. 需要进一步的研究来澄清维生素C和OA发育之间的关系.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 维生素C在骨关节炎 (OA) 发病过程中的作用仍在争论中.
- 现有研究提出了关于维生素C对OA的影响的相互矛盾的证据.
- 这项研究通过整合各种数据集来解决围绕维生素C和OA的不确定性.
研究的目的:
- 调查维生素C摄入量与患骨关节炎的风险之间的关联.
- 使用孟德尔随机化 (MR) 探索维生素C消耗和OA之间的潜在因果关系.
- 提供关于维生素C在关节炎预防或进展中的作用的强有力的证据.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2003-2018) 的横截面分析.
- 后勤回归建模用于评估维生素C摄入量和OA风险.
- 门德尔随机化 (MR) 分析采用三种不同的方法推断因果关系,对可靠性的敏感性分析.
主要成果:
- 对31527名参与者的分析显示,维生素C摄入量 (低,中,高) 与OA风险 (p>0.05) 之间没有统计学上显著的关联.
- 使用逆变量加权 (IVW) 方法进行的MR研究表明,维生素C摄入对OA没有因果关系 (OR = 0.993,p = 0.882).
- 敏感性分析证实了MR发现的稳定性和可靠性.
结论:
- 截面和MR分析都得出结论,维生素C摄入与骨关节炎风险无关.
- 这些发现表明,补充维生素C可能不是预防或治疗OA的可行策略.
- 需要进一步的研究,以充分阐明维生素C和OA之间的复杂相互作用.
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