在儿童和青少年时期的亚托皮炎和烟草烟雾暴露
Noor A Al-Alusi1, Faustine D Ramirez2, Leslie N Chan1
1School of Medicine, University of California, San Francisco, Calif.
The journal of allergy and clinical immunology. Global
|November 7, 2024
概括
这项研究发现,儿童或青少年烟草烟雾暴露与亚托皮性皮炎 (AD) 活动或严重程度之间没有联系. 对影响阿尔茨海默病的环境因素的研究发现,与被动或主动吸烟无关.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 亚托皮炎 (AD) 可能受到烟草烟雾的影响,因为它对免疫反应的影响.
- 以前的研究还没有充分评估烟草烟雾暴露对AD严重程度和生物标志物的影响.
研究的目的:
- 调查儿童和青少年期间被动和主动烟草烟雾暴露 (TSE) 与阿尔茨海默病的活性和严重程度之间的联系.
- 通过重复评估和血清丁胺生物标志物来分析这种关系.
主要方法:
- 利用了来自Avon长度研究父母和儿童的10,521个人的出生队列,通过青春期跟踪.
- 采用混合效应模型来评估与儿童中被动TSE和青少年中活跃TSE相关的AD风险.
- 作为烟草暴露的生物标志物,在三个时间点内纳入血清丁水平.
主要成果:
- 在儿童期被动TSE和并发AD活动之间没有发现显著的关系 (aOR,0.95;95%CI,0.831.07).
- 在青春期没有AD活动的风险增加与活跃的TSE相关 (aOR,0.57;95%CI,0.440.75).
- 二次分析显示没有剂量反应关系或增加AD严重程度与被动或活跃TSE,和没有增加风险累积被动TSE.
结论:
- 无论是活跃的还是被动的烟草烟雾暴露都没有在童年和青春期与亚托皮炎相关.
- 研究结果表明,在这些年龄组中,暴露于烟草烟雾并不是阿尔茨海默病发展或恶化的重要因素.
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