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测量脂质面板的受试者之间的脂质蛋白 (a) 测试模式:梅奥诊所的经验

Matteo Manzato¹, Jeffery W Meeusen², Leslie J Donato²

¹Department of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

American journal of preventive cardiology

|November 7, 2024

概括

脂蛋白 (a) 检测不常见,主要用于二次预防,尽管与动脉样硬化心血管疾病有关,但对患者管理的影响很小. 女性的测试比男性少.

科学领域:

心血管医学心血管医学
临床实验室科学临床实验室科学
流行病学流行病学

背景情况:

脂蛋白 (Lp) 是动脉样硬化心血管疾病 (ASCVD) 的验证风险因素.
升高的Lp (a) 影响大约20%的人口.
对于Lp (a) 的普遍查仍然是一个争论的话题.

研究的目的:

调查美国一家主要的三级保健机构对Lp (a) 的现有实验室测试模式.
分析Lp (a) 测试频率与标准脂质面板一起.
评估Lp (a) 测试的临床利用和影响.

主要方法:

从梅奥诊所的梅奥数据探索器 (MDE) 进行回顾性数据收集.
纳入标准:脂质面板测量时间为2022年5月1日至2023年4月30日.
收集的数据:人口统计,Lp(a) 水平,他类药物/阿司匹林处方,ASCVD事件和Lp(a) 测试订单 (1994-2023年).

主要成果:

只有0.15%的脂质面板受试者在一年内进行了Lp (a) 测试;0.94%的受试者在任何时候都进行了测试.
在男性和有心肌梗塞 (MI) 史的受试者中,Lp (a) 测试更频繁.
在Lp (a) 测试后,无论水平如何,都没有观察到他类药物或阿司匹林处方的显著变化. 二次预防是主要的适应症.

结论:

在一般人群中,检测率仍然很低,主要用于二次预防.
与男性相比,女性对Lp (a) 的检测较少.
升高的Lp(a) 水平往往不会导致改变ASCVD风险减轻的患者管理.

关键词:

动脉样硬化是一种动脉样硬化.脂蛋白 (a) 是一种蛋白质.预防预防预防主要的,主要的.风险评估和降低风险的措施

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