一个当代快照的家族高胆固醇血症注册表
Seyed Saeed Tamehri Zadeh1, Jing Pang1, Dick C Chan1
1Medical School, University of Western Australia, Perth.
Current opinion in lipidology
|November 7, 2024
概括
家庭高胆固醇血症 (FH) 登记显示,大多数患者,包括异合体 (HeFH) 和同合体 (HoFH) 形式的儿童和成年人,被诊断为晚期和治疗不足,无法达到胆固醇目标. 这突显了全球FH护理的关键差距.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学是一种遗传学.
- 公共卫生 公共卫生
背景情况:
- 家族性高胆固醇血症 (FH) 是一种遗传性疾病,导致高的LDL-C水平.
- 来自FH注册表的现实数据为临床实践和患者结果提供了洞察力.
- 登记册对于识别临床指南与实际患者护理之间的差异至关重要.
研究的目的:
- 审查主要家族高胆固醇血症注册的最新发现.
- 了解FH的现实世界流行病学和管理.
- 为了识别全球FH患者护理连续性的差距.
主要方法:
- 从主要的家族高胆固醇血症登记处系统审查数据.
- 对现实实践,流行病学,自然史和治疗结果的分析.
- 评估FH患者的级联测试和心血管后果.
主要成果:
- 大多数成年异合体FH (HeFH) 患者的诊断迟到,治疗不足,并且无法达到推的LDL-C目标.
- 同卵同胞性FH (HoFH) 患者也接受了低于最佳的治疗,在低收入国家治疗差距更大.
- 与女性相比,患有HeFH的男性患动脉样硬化心血管疾病的风险更高.
结论:
- 来自FH注册表的不断变化的数据提供了必要的现实世界的证据.
- 需要实施战略来解决FH护理中发现的差距.
- 在全球范围内改善FH患者的持续护理是优先事项.
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