评估METS-IR用于预测未来糖尿病发病的有效性:使用时间依赖的接收器操作特征进行分析
Jiajun Qiu1, Shiming He1,2, Changhui Yu1,2
1Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
BMC endocrine disorders
|November 7, 2024
概括
代谢性胰岛素抵抗评分 (METS-IR) 有效地预测了未来的糖尿病风险,特别是在女性和年轻人中. 这一分数为不同人群的早期糖尿病检测提供了宝贵的见解.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 预防医学 预防医学
背景情况:
- 代谢性胰岛素抵抗评分 (METS-IR) 是一种新的,非侵入性的胰岛素抵抗 (IR) 标记.
- 以前的研究表明,METS-IR与患糖尿病的风险增加有关.
研究的目的:
- 评估METS-IR对未来糖尿病发展的预测能力.
- 调查各种性别,年龄和BMI群体中METS-IR预测值的时间差异.
主要方法:
- 对来自NAGALA队列的15453名非糖尿病人的分析.
- 根据世卫组织的年龄和BMI标准进行分层.
- 应用多变量考克斯回归和时间依赖的ROC曲线进行风险评估.
主要成果:
- 增加的METS-IR显著预测了未来糖尿病的发展 (观察了373例).
- 在女性和45岁以下的个体中,METS-IR与糖尿病风险之间的关联更为强烈.
- 在随访期间,METS-IR对女性和年轻人进行了更高的预测准确性;随着时间的推移,预测值因BMI类别而异.
结论:
- 在非糖尿病人群中,METS-IR 是未来糖尿病的独立预测器.
- METS-IR在识别患糖尿病风险较高的女性和45岁以下的个人方面特别有用.
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