针对急性肝衰竭的儿科肝移植:定义标准营养和临床演变:一项观察性研究
Patrícia Zamberlan1, Maria A C Bonfim1, Uenis Tannuri2
1Division of Nutrition/Nutritional Support Team, Instituto da Criança e do Adolescente, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
概括
大多数儿科急性肝衰竭 (PALF) 患者在肝移植 (LT) 时有足够的营养. 然而,一些在住院期间恶化,突出需要早期营养治疗 (NT) 后LT更好的结果.
科学领域:
- 儿科肝病学 儿科肝病学
- 临床营养学 临床营养学
- 移植医学 移植医学
背景情况:
- 儿科急性肝衰竭 (PALF) 是一种严重的疾病,其特点是儿童的肝功能迅速下降.
- 肝移植 (LT) 是PALF患者的一种拯救生命的干预.
- 了解营养状况对于管理PALF和优化LT后结果至关重要.
研究的目的:
- 评估PALF患者在入院和住院期间的临床和营养状况.
- 研究在接受LT的PALF患者的营养状况和临床结果之间的关系.
- 为了确定在儿科肝衰竭中进行营养干预的关键时期.
主要方法:
- 对为PALF接受LT的儿科患者进行前性研究.
- 连续营养评估,包括z-score 体重指数-按年龄和z-臂周长-按年龄 (zAC/A).
- 评估临床结果及其与血清白蛋白和C反应蛋白等营养参数的相关性.
主要成果:
- 大多数PALF患者 (82.6%) 根据BMI和zAC/A.在入院时表现出足够的营养状况.
- 近一半 (47.6%) 的患者在住院期间营养状况下降,由zAC.
- 在初始营养状况和临床结果之间没有发现统计学意义上的关联.
结论:
- 虽然许多PALF患者在LT中营养良好,但在住院期间,很大一部分患者的营养水平下降.
- 在LT后住院是营养状况恶化的高风险时期.
- 早期和积极的营养疗法 (NT) 对于改善儿科肝衰竭患者的治疗结果至关重要.
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