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Updated: Jun 8, 2025

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发现PTEN缺陷前列腺癌的CHD1对手

Rebecca L Johnson1, Amanda L Graboski2, Fengling Li3

  • 1Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Journal of medicinal chemistry
|November 7, 2024
PubMed
概括

研究人员发现了UNC10142,一种新的小分子对抗剂,向CHD1染色体. 这种化合物有效地降低了缺少PTEN的前列腺癌细胞的活力,突出了CHD1作为治疗点.

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