新诊断的皮质下变化以及大脑连接和认知的相关变化
Christophe E de Bézenac1, Nicola Leek1, Guleed H Adan1,2
1Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Human brain mapping
|November 7, 2024
概括
皮下缩,特别是在丘脑,在诊断时存在,并与白质变化和认知缺陷有关. 这些早期的大脑变化表明,发性过程本身的影响.
科学领域:
- 神经成像是一种神经成像.
- 的研究研究.
- 认知神经科学 认知神经科学
背景情况:
- 慢性焦点往往涉及皮下缩,特别是在丘脑.
- 诊断时这些结构变化对大脑连接和认知功能的时间和影响尚不清楚.
研究的目的:
- 用表面形状分析研究新诊断的焦点 (NDfE) 中局部下皮层缩.
- 评估这些形态变化,白质完整性和神经心理结果之间的关系.
主要方法:
- 结构和扩散加权的MRI和神经心理数据来自104名NDfE患者和45名健康对照 (HC).
- 下皮层结构的基于顶点的形状分析和相关性曲谱学.
- 对形状和神经心理学数据的通用法定相关性分析.
主要成果:
- 与HC相比,NDfE患者的前丘脑和右的双边向内变形 (缩) 与HC相比.
- 减少了与缩相关的白质连接到 thalamus 和 pallidum 的通道中的微分异质 (FA).
- 乳头和形状的变化与增加的抑郁,焦虑和记忆和认知功能的减少有关.
结论:
- 在诊断时可能存在thalamic缩,与白质变化和认知障碍相关.
- 早期的大脑结构变化及其认知影响可能源于发作过程,而不仅仅是慢性或治疗.
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