综合征患者中风风险因素:波兰两个中心的经验
Michael Kitlinski1, Zbigniew Heleniak1, Aleksander Och1
1Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.
概括
患有性综合征的患者面临更高的中风风险. 关键的危险因素包括年龄,糖尿病,先前的动脉血栓栓塞事件和吸烟. 低分子量肝素没有显示任何保护作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 神经学 神经学
- 心血管医学 心血管医学
背景情况:
- 性综合征 (NS) 显著增加了急性缺血性中风 (aIS) 和内出血 (ICH) 的风险.
- 确定NS患者中风的特定风险因素对于有效的患者管理和风险分层至关重要.
研究的目的:
- 在被诊断为综合征的患者中确定与中风 (aIS或ICH) 发展相关的关键风险因素.
- 为管理NS患者的临床医生提供基于证据的见解,这些患者有脑血管事件的风险.
主要方法:
- 一项多中心的回顾性队列研究包括2010年至2021年间诊断的NS患者,将那些经历中风的人与那些没有经历中风的人进行比较.
- 考克斯回归分析用于确定显著的风险因素,计算危险比率 (HR) 和95%置信区间 (CI).
- 对现有文献进行了元分析,以证实在NS患者中发生动脉血栓栓塞事件 (ATEs) 的风险因素的发现.
主要成果:
- 在NS患者中,中风的重要危险因素包括糖尿病 (DM) (HR 2.85),糖尿病病 (HR 2.74),吸烟 (HR 8.29),先前的动脉血栓栓塞事件 (ATEs) (HR 2.86),以及55岁以上的年龄 (HR 4.84).
- 低分子量肝素 (LMWH) 给药没有显著影响中风风险 (HR 0.88).
- 对1091名患者的分析证实了先前的ATEs,糖尿病,高血压和吸烟是NS患者ATEs的风险因素.
结论:
- 高龄,糖尿病,有动脉血栓栓塞病史和吸烟是患有性综合征的患者中风的重要危险因素.
- 在这种人群中,低分子量肝素似乎没有提供对中风的保护作用.
- 这些发现有助于识别和管理高风险的NS患者,以预防中风.
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