简单的口腔拔牙对马体血清粉样蛋白A度的影响
Amelia E Sidwell1,2, Marco Duz1, Adeel Khan1
1School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
Veterinary medicine and science
|November 7, 2024
概括
马的牙提取不会显著增加血清粉样蛋白A (SAA),除非出现牙周病. 这表明马的牙周病可以导致全身炎症.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 马类牙科 马类牙科
- 免疫学 免疫学 免疫学
背景情况:
- 系统性炎症可能是由于口腔细菌的转移而产生的,这种转移发生在患有牙周疾病等牙疾病的动物身上.
- 虽然马的常规牙科手术不会提高血清粉样蛋白A (SAA),但提取可能表明严重牙科疾病的更广泛的全身影响.
研究的目的:
- 为了调查血清粉样蛋白A (SAA) 水平是否在牙切除后增加,与或没有同时出现牙周病.
主要方法:
- 进行了一项前性队列研究,涉及马和小马进行简单的口腔牙拔除.
- 血清粉样蛋白A (SAA) 在基线,24小时和提取后48小时使用机侧测试进行测量.
主要成果:
- 在抽取24小时和48小时后,在患有牙周病和没有牙周病的马之间观察到SAA度的统计学上显著差异.
- 与没有牙周病的马匹相比,患有牙周病的马匹的中位数SAA水平显著更高 (24小时135毫克/升,48小时264毫克/升),比没有牙周病的马匹高 (27.5毫克/升24小时,48小时0毫克/升).
结论:
- 拔除非骨折的牙通常不会导致SAA显著增加,除了牙周病例.
- 这些发现表明,马的牙周病与局部炎症有关,可以引发全身炎症,牙组织干扰后炎症标志物升高证明了这一点.
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