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综合营养不良指数用于预测接受新辅助化疗或放射治疗的局部晚期直肠癌患者的临床结果

Yu Xu¹, Peipei Shen¹, Jiahao Zhu¹

¹Department of Radiotherapy and Oncology, The Affiliated Hospital of Jiangnan University, Wuxi, China; Wuxi Clinical Cancer Center, Wuxi, China.

Biomolecules & biomedicine

|November 7, 2024

概括

综合营养指数 (CNI) 是接受新辅助化学放射治疗 (nCRT) 和手术的局部晚期直肠癌 (LARC) 患者的生存的一个强有力的预测指标. 更高的CNI表明更好的无病生存率和整体生存率,指导治疗决策.

科学领域:

在瘤学瘤学.
营养科学营养科学
手术瘤学手术瘤学

背景情况:

局部晚期直肠癌 (LARC) 治疗包括新辅助化学放射治疗 (nCRT),然后进行手术.
营养状况显著影响癌症患者的治疗结果和生存率.
现有的营养指数可能无法完全捕捉影响LARC预后的因素的复杂相互作用.

研究的目的:

评估LARC患者综合营养指数 (CNI) 的预后意义.
将CNI的预测能力与其他营养标志物的生存结果进行比较.
为了确定CNI是否影响术后化疗的益处.

主要方法:

主要成分分析被用来从血红蛋白,淋巴细胞总数,白蛋白,BMI和通常的体重百分比来得出CNI.
240名接受nCRT和手术治疗的LARC患者被追溯分析.
进行了考克斯回归和生存分析,以评估预后价值和治疗相互作用.

主要成果:

与其他指数相比,CNI显示出无病生存期 (DFS) 和整体生存期 (OS) 的优异预测能力.
高CNI的患者比低CNI的患者表现出明显更长的DFS和OS.
CNI是DFS (HR=0.49) 和OS (HR=0.30) 的独立预后因素.
高CNI组从术后化疗中受益,与低CNI组不同.

结论:

综合营养指数 (CNI) 是接受nCRT和手术的LARC患者的有价值的预后指标.
CNI分层可以帮助识别可能从特定辅助疗法中受益的患者.
术前营养优化对于改善LARC患者的治疗结果至关重要.

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