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天然状骨位置和手术重新定位对上呼吸道通透性的影响:一项计算有限元素建模研究

Diane Salman¹, Jason Amatoury¹

¹Sleep and Upper Airway Research Group (SUARG), Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture (MSFEA), American University of Beirut, Beirut, Lebanon.

Journal of applied physiology (Bethesda, Md. : 1985)

|November 7, 2024

概括

任何从自然的舌骨位置的变化都会使阻塞性睡眠呼吸暂停 (OSA) 的上呼吸道缩性恶化. 手术状腺重新定位 (SHR) 的有效性取决于状腺.

科学领域:

生物力学生物力学
计算建模计算建模
睡眠的药物睡眠的药物

背景情况:

基线下状腺位置与阻塞性睡眠呼吸暂停 (OSA) 有关.
手术状腺重新定位 (SHR) 用于治疗OSA,但结果各不相同.
基线下垂体位置 (BHP) 和SHR对上呼吸道 (UA) 功能的影响尚未完全理解.

研究的目的:

通过计算建模研究BHP和SHR对UA功能的影响.
为了确定舌移位的方向和大小如何影响UA的折叠性和机械.
探索BHP与SHR在OSA治疗中的有效性之间的关系.

主要方法:

开发了一种验证的子上呼吸道的有限元模型.
进行模拟来评估BHP和SHR的变化,单独和组合.
在头骨,尾骨,前部,前部-头骨和前部-尾骨方向 (1-4毫米) 中模拟了状骨的位移.
测量结果包括上呼吸道折叠性 (关闭压力;Pclose),横截面积 (CSA) 和软组织力学.

主要成果:

增加的BHP提升了Pclose,表明UA的可折叠性更大.
基于前面的SHR显著降低了Pclose,增加了CSA.
头骨和尾部SHR对Pclose和CSA产生了不同的影响.
SHR的影响取决于BHP,更多的尾部基线位置导致手术效果较差.
前和前尾SHR产生了最高的软组织应力和应变.

结论:

无论是BHP (表型) 还是SHR都会显著改变UA结果.
SHR的有效性受状腺的方向,大小和基线位置的影响.
考虑BHP和量身定制手术重新定位可能会改善OSA的舌手术结果.
这项研究突出了状骨在UA通透性和OSA治疗中的关键作用.

关键词:

关闭压力的关闭压力阻塞性睡眠呼吸暂停 (OSA) 是一种模拟模拟是指一个模拟模拟.组织力学组织力学上呼吸道外科手术上呼吸道手术

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