关于人体血聚二乙烯 (PBDE) 与甲状腺平衡和甲状腺癌之间的关联的研究
Qianqian Wang1,2, Yi Wang2, Chunyan Chen2
1Jinzhou Medical University Graduate Training Base (Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine), 121001, Jinzhou, People's Republic of China.
Environmental geochemistry and health
|November 7, 2024
概括
某些聚化乙烯 (PBDE) 的血水平与甲状腺功能和更具侵略性的甲状腺癌病理相关. 这表明PBDE可能会影响甲状腺健康和癌症的进展,但不是通过常见的遗传突变.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 聚二乙烯 (PBDE) 是一种持久性有机污染物 (POP),具有已知的内分泌干扰和促进瘤的活动.
- 将人体血PBDE水平与甲状腺平衡和甲状腺癌联系在一起的证据有限.
- 了解PBDE对甲状腺健康的影响是非常重要的,因为它们在环境中无处不在.
研究的目的:
- 研究血PBDE同源水平与甲状腺功能之间的关联.
- 探索甲状腺癌患者的血PBDE和病理参数之间的相关性.
- 为了检查PBDE和常见的基因突变 (BRAF,RAS) 在乳头甲状腺癌 (PTC) 之间的关系.
主要方法:
- 从53名甲状腺手术患者的血样本中分析了8种PBDE原体.
- 统计分析包括点-二次相关性和贝叶斯核-机器回归 (BKMR).
- 评估与甲状腺激素水平 (FT3) 和瘤病理特征的关联.
主要成果:
- BDE-209是检测到的最丰富的PBDE同源.
- 在BDE-100和自由三甲状腺胺 (FT3) 之间发现了积极的关联,表明甲状腺功能干扰.
- 几种PBDE原体 (BDE-28, -47, -99, -100, -154) 与侵袭性病理参数有关.
- 在PTC患者中,PBDE和BRAF或RAS突变之间没有显著的相关性.
- BKMR分析表明BDE-47,BDE-99和恶性瘤风险之间存在潜在的积极关联.
结论:
- 血PBDE水平可能会干扰甲状腺功能.
- 暴露于特定的PBDE原体与更具侵略性的甲状腺癌病理学有关.
- 通过BRAF/RAS突变,PBDE可能不会直接驱动甲状腺癌的发病.
- 需要进一步的大规模前性研究来证实这些发现.
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