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在糖尿病病中TRIM22的诊断价值及其机制
Qianhui Wang1, Qingmiao Ge1, Jingjing Wang1
1Department of Nephropathy, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Endocrine
|November 7, 2024
概括
含有22 (TRIM22) 的三部分基因是糖尿病病 (DKD) 的有前途的生物标志物. 这项研究确定TRIM22是DKD患者管间间损伤和自功能障碍的关键指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 糖尿病病 (DKD) 是全球慢性病的主要原因.
- 管间伤害是DKD进展的关键因素.
- 自在DKD病变发生过程中起着重要作用.
研究的目的:
- 确定DKD中管间伤害的新型自相关生物标志物.
- 评估在DKD诊断和预后中确定生物标志物的临床实用性.
主要方法:
- 使用的基因表达综合数据集 (GSE104954,GSE30122,GSE30529,GSE99340) 用于生物信息学分析.
- 使用LASSO和SVM-RFE算法选与自相关的差异表达基因 (ARDEG).
- 在临床DKD样本和高葡萄糖刺激的HK-2细胞中通过免疫组织化学,免疫光和西部斑点验证了TRIM22表达.
主要成果:
- 通过ROC曲线分析确定了四种ARDEG,其中TRIM22通过ROC曲线分析证明了DKD的最高诊断疗效.
- 在临床DKD样本和体外模型中观察到TRIM22蛋白表达升高.
- 在TRIM22和自的指标 (SQSTM1,NGAL) 和DKD病理学之间发现了显著的相关性.
结论:
- TRIM22是DKD的潜在诊断生物标志物,特别是在中度至重度间歇性纤维化和管状缩 (IFTA) 患者中.
- TRIM22与DKD特有的管间损伤和自失调有关.
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