童年社区的劣势和MRI-derived结构性大脑完整性在65岁后的年龄
Rachel L Peterson1, Erika Meza2, Kristen M George3
1University of Montana, Missoula.
JAMA network open
|November 7, 2024
概括
童年社区的劣势与晚年大脑健康状况较差有关,即使考虑到个人收入和教育水平. 这种联系凸显了早期生活环境对认知衰老的持久影响.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 社会学 社会学 社会学
背景情况:
- 以前的研究将晚年社区的劣势与大脑健康的下降联系在一起.
- 童年社区劣势对晚年大脑健康的影响仍然不太了解.
研究的目的:
- 研究在经济不利的社区成长与晚年大脑健康之间的关联.
- 检查个人社会经济因素 (收入,教育) 如何影响这种关系.
主要方法:
- 一项使用KHANDLE和STAR研究数据的队列研究 (N=2161,年龄65岁以上).
- 儿童社区劣势是使用区域贫困指数 (ADI) 定义的.
- 通过MRI评估大脑健康,测量皮质大脑体积和白质完整性,根据种族,种族和父母教育进行调整.
主要成果:
- 童年社区的劣势与几个大脑区域的灰质体积较小有关,包括小脑,海马和皮质.
- 来自弱势儿童社区的参与者表现出较大的侧腔和第三心室,以及白质超强度体积增加.
- 这些关联是独立于个人的教育程度和晚年收入而存在的.
结论:
- 童年居住在弱势社区是一个独立的风险因素,导致晚年大脑健康恶化.
- 研究结果表明,早期社会经济环境对大脑结构和完整性有着显著的长期影响.
- 建议进行进一步的研究,以探索调解因素,如心血管健康,以解释这些观察到的关联.
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