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Updated: Jun 8, 2025

Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions
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Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions

Published on: January 30, 2018

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通过多组合马尔科夫模型改进了折叠稳定性和动力学的估计

Si Zhang1, Yunhui Ge1, Vincent A Voelz1

  • 1Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, United States.

Biochemistry
|November 7, 2024
PubMed
概括

这项研究引入了马尔科夫状态模型 (MSM) 的新增采样协议,以准确地从模拟中预测蛋白质折叠稳定性. 该方法改进了传统的MSM,通过结合不偏见的折叠和雨采样来获得更可靠的结果.

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