在小鼠中,半球间的桃体-accumbens 电路编码了负值
Zhen Tian1,2, Jiachen Song1,2, Xuying Zhao1,2
1School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200032, China.
Science (New York, N.Y.)
|November 7, 2024
概括
大脑中半球间的连接,就像前半球 (AC) 一样,在行为中起着不同的作用. 这项研究揭示了基底侧桃体 (BLA) 如何使用逆侧路径来产生厌恶,以及逆侧路径来获得奖励.
科学领域:
- 神经科学
- 行为神经科学
- 神经解剖学
背景情况:
- 哺乳动物的大脑半球在结构上是对称的,但在功能上是不同的.
- 通过指导轴突介导的半球间连接对于大脑功能至关重要.
- 在行为中,像前 (AC) 这样的路径的具体作用尚未完全被理解.
研究的目的:
- 通过前部指针 (AC) 调查半球间连接的功能意义.
- 阐明从底侧桃体 (BLA) 到核 (NAc) 的异面和反面投影的不同作用.
主要方法:
- 在小鼠中切割前 (AC).
- 从底侧桃体 (BLA) 到核 (NAc) 的突出的分析.
- 选择性激活神经元通路并测量NAc中的多巴胺水平.
主要成果:
- 前部指针 (AC) 切割损害了避开行为.
- 通过厌恶刺激激活的反侧BLA-NAc投射,准D2-MSN,降低NAc多巴胺,并诱导厌恶.
- 通过积极刺激激活的ipsilateral BLA-NAc投射,准D1-MSN,增加NAc多巴胺,并诱导奖励.
结论:
- 反侧BLA-AC-NAc通路对于编码负价值是必不可少的.
- 半球内和半球间电路在处理价值和指导行为中的不同功能.
- 突出了半球通信在大脑生理中的特殊作用.
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