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Updated: Jun 8, 2025

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

可定制的基于酸盐微纤维的水.

Zhenxiu Liu¹, Yong Mei Chen¹, Wenjun Shu²

¹College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science &Technology, Xi'an, Shaanxi 710021, China.

Journal of colloid and interface science

|November 7, 2024

概括

研究人员开发了可定制的基托微纤维 (CMF) 基水,模仿软组织特性. 这些多孔生物材料为植入物支架提供了出色的自我恢复和生物相容性.

关键词:

可定制的可定制的液体海绵是一种水性海绵.有孔的生物材料.快速的自我恢复速度.剪裁削减削减削减削减削减削减削减

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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

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科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
组织工程是组织工程.

背景情况:

可定制和粘弹性多孔生物材料对于修复大体积组织缺陷至关重要.
现有的脚手架往往缺乏用于软组织再生所需的机械性能和自我恢复能力.

研究的目的:

开发基于酸盐微纤维 (CMFs) 的新型水,具有可调节的机械性能和出色的自我恢复能力.
评估血红相容性,细胞相容性,生物降解性,以及生物医学应用中作为植入物支架的潜力.

主要方法:

素微纤维 (CMF) 通过高速剪切合成并结晶.
使用共价 (甘油三甘乙烯 - GTE) 和键来交叉链接CMF,形成水.
评估了机械性能,自我恢复,可定制性 (2D/3D架构),体外生物相容性 (血液溶解,细胞分析) 和体内生物降解性.

主要成果:

由此产生的水体表现出与软组织相比的机械性能,并在大压缩后快速自我恢复 (1s).
CMF悬架显示了剪切稀释行为,使得各种可定制的2D和3D架构的制造成为可能.
在体外和体内研究证实了出色的血红相容性,细胞相容性,无毒性,生物降解性和缺乏炎症反应.

结论:

基于CMF的水提供了一个有希望的,绿色的,可大规模生产的平台,用于创建可定制的植入物支架.
弹性,海绵状的吸水能力和快速自我恢复的独特组合使它们适合生物医学应用.
这些发现为使用先进生物材料的先进组织工程解决方案铺平了道路.