针对结肠的自组装纳米颗粒装有柏柏林双盐,通过改善肠道粘膜屏障和肠道微生物群来改善性结肠炎
Yalong Wang1, Yan Chen1, Hongjuan Zhang1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Colloids and surfaces. B, Biointerfaces
|November 7, 2024
概括
本研究提出了用于治疗性结肠炎 (UC) 的新型纳米颗粒,有效向结肠炎症并改善肠道健康. 双重向的纳米粒子在临床前模型中显示出显著的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠道疾病,其粘膜壁垒受损,并导致失活性.
- 目前的治疗主要针对炎症,并且往往无法解决多因素UC病理.
- 需要先进的药物输送系统来针对性地输送结肠.
研究的目的:
- 开发和评估双重向,自组装的纳米颗粒用于口服治疗性结肠炎.
- 为了增强治疗剂的溶解性和结肠向性,如柏柏林和ursodeoxycholic酸.
- 研究这些纳米颗粒在改善肠道屏障功能,减少炎症和调节肠道微生物群方面的有效性.
主要方法:
- 通过纳米沉和封装在耐酸基酸盐微球 (FU-PA/BeU NPs@MS) 中制备FU-PA/BeU纳米颗粒.
- 在实验室中评估纳米粒子-粘液相互作用,巨细胞向,抗炎和抗氧化活性.
- 在硫酸 (DSS) 诱导的UC小鼠模型中的体内评估,评估结肠长度,屏障完整性,微生物群,炎症和氧化应激.
主要成果:
- 与自由柏柏林相比,FU-PA/BeU NPs@MS显示粘液聚合减少和透性提高.
- 试验室研究显示,有效向炎症性巨细胞,显著减少IL-6和NO,增加IL-10.
- 在体内,与sulfasalazine相比,FU-PA/BeU NPs@MS显著改善了粘膜壁垒,恢复了肠道微生物群,减少了炎症和氧化应激,并增加了结肠长度.
结论:
- 双重向的FU-PA/BeU NPs@MS代表了对性结肠炎的有前途的纳米治疗策略.
- 这种方法有效地解决了UC的多种病理方面,包括炎症,氧化应激和屏障功能障碍.
- 针对性输送系统提高了治疗效率,并有可能改善UC管理中的患者结果.
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