多酶模拟Fe单原子纳米酶调节感染微环境,用于光热增强的催化抗菌疗法
Na Li1, Jing Tang2, Congxiao Wang3
1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital & Center for Molecular Imaging Probe & Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Colloids and surfaces. B, Biointerfaces
|November 7, 2024
概括
高活性铁单原子纳米酶被开发用于感染治疗. 这些纳米酶产生活性氧物种 (ROS),并利用光热效应增强抗菌活性和生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 催化剂是一种催化剂.
背景情况:
- 设计纳米酶以有效生成活性氧物种 (ROS) 仍然是治疗耐药感染的挑战.
- 感染的微环境往往阻碍了有效的抗微生物策略.
研究的目的:
- 开发具有高度活性的铁单原子纳米酶 (Fe SAzymes),具有层次的多孔纳米结构.
- 研究催化活性和光热特性对增强抗菌疗法的协同效应.
主要方法:
- 用合体二氧化诱导的模板方法合成FeSAzymes.
- 评估氧化酶类,过氧化酶类和谷氨过氧化酶类活性.
- 评估ROS生成,杀菌作用和光热特性.
- 在体外和体外的抗菌疗效和生物相容性研究.
主要成果:
- 铁SA酶表现出高的氧化酶类和过氧化酶类活性,将O2和H2O2转化为ROS (•O2−和•OH).
- Fe SAzymes的氨酸过氧化酶类活性消耗了氨酸,进一步促进了ROS生成和绝育.
- 铁SA酶的内在光热效应显著增强了ROS的产生和抗菌功效.
- 在体外和体外的研究都证实了FeSA酶的令人满意的抗菌作用和良好的生物相容性.
结论:
- 具有层次多孔纳米结构的Fe SA酶为对抗耐药性感染提供了一个有前途的策略.
- 光热和催化活动的协同组合导致高效的ROS生成用于杀菌.
- 这项工作为设计先进的单原子纳米酶提供了宝贵的见解,用于有效的抗菌应用.
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