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在自闭症的词典语义任务期间,功能连接的异质性增加和与任务相关的重构

Apeksha Sridhar¹, R Joanne Jao Keehn¹, Molly Wilkinson¹

¹Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, CA, United States.

NeuroImage. Clinical

|November 7, 2024

概括

自闭症谱系障碍 (ASD) 涉及改变的大脑网络连接. 这项研究发现,自闭症患者在语言任务中表现出更大的功能连接性重新配置,这表明网络组织效率低下.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
认知科学认知科学

背景情况:

自闭症谱系障碍 (ASD) 在原因和症状方面呈现出显著的异质性.
以前对自闭症功能连接 (FC) 的研究已经产生了不一致的结果,观察到过度和不足的连接.
在休息状态和任务状态 (重新配置) 之间检查FC的变化提供了一种新的方法来理解ASD中的网络低效率.

研究的目的:

研究与典型发展 (TD) 个体相比,在ASD青少年的词典语义决策任务期间的功能连接性 (FC) 重构.
探索FC重新配置,任务执行和ASD语言技能之间的关系.
了解ASD内部网络动态中个体间的变化.

主要方法:

功能磁共振成像 (fMRI) 用于测量30名ASD青少年和23名TD参与者的大脑活动.
参与者在接受fMRI扫描时完成了一项词汇语义决策任务.
在选定的感兴趣区域分析了休息和任务状态之间的功能连接 (FC) 和FC重新配置.

主要成果:

与TD组相比,ASD组表现出更大的个人间变异性和整体更高的FC重新配置.
一个具有典型性能准确性的ASD子组在任务中显示了CF的相似性和典型性.
在这个高表现的ASD小组中,增加的FC重新配置与增强的语言技能相关.

结论:

在ASD中,内在的大脑网络可能在词汇语义处理方面组织得不高效,因此在任务中需要更大的重新配置.
在一些患有自闭症的个体中,高性能可能通过独特或特异性的网络机制实现.
FC重新配置是理解ASD网络动态和行为功能的一个有价值的指标.

关键词:

自闭症自闭症自闭症执行官的功能障碍.功能连接MRI功能连接奇特的同步感是什么意思词汇决策任务词汇决策任务神经网络重新配置神经网络重新配置

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