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Updated: Jun 8, 2025

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皮表皮质角质细胞特异性的PD-L1淘汰会导致糖尿病伤口的愈合延迟

Zhan Zhang1, Dan Yang2, Fang Shen2

  • 1Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Institute of Dermatology, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.

International immunopharmacology
|November 7, 2024
PubMed
概括

皮肤细胞 (角质细胞) 中的PD-L1对于治愈糖尿病 (DUs) 是至关重要的. 过度表达PD-L1会加速DU的愈合,而其缺乏会损害它,为慢性伤口提供新的治疗策略.

关键词:
糖尿病病人的伤口.炎症 炎症是一种炎症.角质细胞 (keratinocytes) 是一种细胞.在PD-L1中.重新上皮质化的发生.

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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