对SARS-CoV-2抗原反应的演变从XBB转变为JN.1
Fanchong Jian1,2,3, Jing Wang1,2,4, Ayijiang Yisimayi1,2,4
1Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China.
Nature
|November 7, 2024
概括
与XBB相比,JN.1 SARS-CoV-2变种表现出不同的免疫反应,而JN.1感染对自身的亚变种提供了更好的中和. 由于KP.3等变种的免疫规避,需要进行增强更新.
科学领域:
- 免疫学
- 病毒学
- 疫苗学
背景情况:
- SARS-CoV-2 持续演变,其中 JN.1 血统继承了 XBB.
- 了解对新型病毒的免疫反应对于疫苗开发至关重要.
研究的目的:
- 分析对XBB和JN.1暴露的体内免疫反应.
- 评估抗体对新出现的SARS-CoV-2变种的有效性.
主要方法:
- 对XBB和JN.1的血中和分析.
- 深度突变扫描抗体表位.
- B细胞受体谱的表征.
主要成果:
- 与XBB相比,JN.1感染对其子变体产生更强的中和作用.
- KP.3 具有显著的免疫逃避和受体结合能力.
- JN.1-诱导的B细胞具有优势;然而,KP.2和KP.3会逃避一些JN.1-诱导的抗体.
结论:
- 抗原从XBB转变为JN.1需要重新评估疫苗的成分.
- 应考虑使用JN.1系,特别是KP.2和KP.3系的疫苗增剂.
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