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对累积暴露和认知障碍的DNA甲基化生物标志物

Kanghong Shao¹, Yu Yu², Beate Ritz³

¹Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.

Environmental research

|November 7, 2024

概括

累积的暴露会对老年人的认知功能产生负面影响. 这项研究使用DNA甲基化来估计水平,发现与较低得分的关联,特别是在女性和APOE4载体中.

科学领域:

神经科学是一个神经科学.
环境健康环境健康
遗传学是一个遗传学.

背景情况:

越来越多的证据将低水平的暴露与老年人的认知能力下降联系在一起.
测量骨的传统方法对于大型社区研究是不可行的.
这项研究引入了一种新的DNA甲基化方法来估计暴露.

研究的目的:

在阿尔茨海默病神经成像倡议 (ADNI) 队列中使用DNA甲基化生物标志物估计骨和血液中的含量.
研究估计的水平与随时间推移的认知功能之间的关联.
探索这种关联中的潜在的性别和APOE4基因型差异.

主要方法:

用DNA甲基化生物标志物估计了625名ADNI参与者的骨,骨和血水平.
用蒙特利尔认知评估 (MoCA) 评估认知功能.
纵向分析采用了线性混合效应回归模型.

主要成果:

由DNA甲基化衍生出的骨和骨含量与MoCA得分有负相关性.
较高的DNAm带与较低的MoCA得分有关 (β = -0.23每IQR).
这种关联在女性和具有一个或两个APOE4等位基因的个体中更为明显.

结论:

累积的暴露与老年人的认知功能下降有关.
女性和APOE4载体对的认知影响的脆弱性增加.
在流行病学研究中,DNA甲基化为评估暴露提供了一种可行的方法.

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