在儿科肥胖症和普拉德-威利综合征中探索与睡眠有关的呼吸障碍
Gintare Oboleviciene1, Laimute Vaideliene2, Valdone Miseviciene2
1Lithuanian University of Health Sciences, Medical Academy, Pediatric Department, Kaunas, Lithuania.
Respiratory medicine
|November 7, 2024
概括
患有普拉德-威利综合征 (PWS) 的儿童和肥胖儿童都面临着与睡眠有关的呼吸障碍 (SRBD) 的高风险. 中央睡眠呼吸暂停和低通风在PWS中更常见,但阻塞性睡眠呼吸暂停在两组中都很普遍.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 睡眠医学 睡眠医学
- 遗传学 遗传学 是一个
背景情况:
- 肥胖是儿童睡眠相关呼吸障碍 (SRBD) 的重要危险因素.
- 普拉德-威利综合征 (PWS) 是一种遗传性疾病,通常与肥胖和潜在的睡眠障碍有关.
研究的目的:
- 为了比较患有PWS的儿童中SRBD的临床和诊断特征与没有PWS的肥胖儿童.
- 了解肥胖作为这些儿科群体中睡眠呼吸暂停的统一风险因素的作用.
主要方法:
- 一个回顾性队列研究,涉及2岁及以上的儿童,确认PWS或非PWS肥胖症.
- 对58名符合条件的儿童收集和分析了临床数据和多睡眠记录 (PSG).
- 睡眠呼吸暂停类型的比较,睡眠效率和PWS和非PWS肥胖群体之间的碎片化.
主要成果:
- 阻塞性睡眠呼吸暂停 (OSA) 的患病率在两组中都很高 (97.2%的非PWS肥胖者,72.7%的PWS).
- 中央睡眠呼吸暂停 (CSA) 和与睡眠相关的低通风在患有PWS的儿童中明显更常见 (分别为OR4.35和4.66).
- PWS患者的睡眠效率更高,睡眠碎片化与更高的呼吸暂停-低呼吸指数 (AHI) 仅在非PWS肥胖儿童中相关.
结论:
- 无论是PWS还是非PWS的肥胖儿童,都具有SRBD的高风险,需要进行多睡眠学 (PSG) 查.
- 虽然OSA在两种情况下都很常见,但PWS患者更有可能出现CSA和低通风.
- 特别是在青春期,SRBD的风险强调了这些儿科组及时诊断和管理的重要性.
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