连接COVID-19和癌症:潜在的机制
Sourabh Tyagi1, Nipanshi Tyagi2, Anu Singh2
1Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Biochimica et biophysica acta. Molecular basis of disease
|November 7, 2024
概括
这篇评论探讨了COVID-19和癌症之间的联系. 感染SARS-CoV-2可能会增加癌症风险和癌症通过诸如细胞因子风暴和免疫抑制等机制的进展,影响瘤生长.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 由SARS-CoV-2引起的COVID-19呈现出各种不同的临床症状.
- 患有先前存在的疾病的患者容易受到SARS-CoV-2感染.
- COVID-19和癌症之间的病理生理相似性表明存在潜在的联系.
研究的目的:
- 审查COVID-19和癌症之间的关联.
- 探索SARS-CoV-2可能影响癌症易感性和进展的机制.
主要方法:
- 关于COVID-19和癌症现有研究的文献综述.
- 分析病毒感染和瘤发生之间的病理生理路径.
主要成果:
- 受体表达 (ACE2,TMPRSS2) 影响了COVID-19的易感性.
- SARS-CoV-2 感染可能通过细胞因子风暴,缺氧,免疫抑制和氧化应激促进癌症.
- 这些机制创造了一个有利于瘤生长,转移和复发的瘤微环境.
结论:
- 感染COVID-19可能会增加癌症风险并加速癌症的进展.
- 了解这些联系对于在疫情期间管理癌症患者至关重要.
- 该审查还涵盖了疫苗的影响和癌症患者正在进行的临床试验.
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