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从发酵的Cordyceps sinensis中获得的多糖类的系统审查:制备的进展,结构特征,生物活性,结构-活性关系

Lumeng Yao¹, Lili Zhu¹, Changlun Chen¹

¹School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.

International journal of biological macromolecules

|November 7, 2024

概括

发酵技术可以生产人造皮质 (发酵的C. sinensis),以满足需求. 来自发酵的C. sinensis的多糖体表现出多样化的生物活性,其结构-活性关系为未来的研究和应用提供了途径.

科学领域:

菌类学菌类学是指菌类学.
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

无菌 (Ophiocordyceps sinensis) 是一种有价值的药用真菌,面临着资源短缺的问题.
发酵技术为生产发酵的C. sinensis (人造皮) 提供了一个可持续的替代方案.
多糖是发酵的C. sinensis中的关键生物活性成分,需要对其特性进行系统审查.

研究的目的:

在过去十年中,系统地审查从发酵的C. sinensis中制备的多糖类的制备,结构特征,生物活性,结构活性关系 (SAR) 和应用.
巩固目前关于发酵的Cordyceps sinensis多糖体 (FCSPs) 的研究.
识别知识差距,并提出未来的研究方向.

主要方法:

在过去十年对FCSP研究的文献综述.
提取,分化,净化和结构特征化技术的分析.
报告的生物活性和SAR的评估.

主要成果:

提取水和酒精沉,然后进行色谱,是常见的FCSP制备方法.
鉴定了34种多糖,包括5种葡萄糖和7种异多糖.
FCSP表现出显著的抗氧化剂,脏保护,免疫调节,抗瘤和低脂活动.

结论:

分子重量,单糖化合物组成和糖键类型对于FCSP生物活性至关重要.
需要进一步的研究来充分阐明FCSPs复杂的SAR.
在健康和医学领域,FCSP具有重要的工业和商业应用潜力.

关键词:

发酵的Cordyceps sinensis是一种未来的前景未来的前景葡萄糖是一种葡萄糖.多糖类多糖化物.

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