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1型糖尿病的学龄儿童和青少年的认知功能:匹配的病例控制横截面研究

Sultan A Meo¹, Metib Alotaibi¹, Narmeen Shaikh¹

¹From the Department of Physiology (Meo); from the Department of Pediatrics (AlKhalifah), College of Medicine, King Saud University, and from the University Diabetes Center (Alotaibi, Shaikh, AlKhalifah), King Saud University Medical City, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Saudi medical journal

|November 7, 2024

概括

患有1型糖尿病 (T1DM) 的儿童和青少年表现出认知表现的延迟. 高血红蛋白A1c (HbA1C) 表示的低血糖控制与T1DM患者的认知功能下降有关.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
儿科儿科儿科

背景情况:

1型糖尿病 (T1DM) 是一种慢性疾病,影响儿童和青少年.
认知功能对于这个年龄段的发展和日常生活至关重要.
了解T1DM对认知的影响对于综合护理至关重要.

研究的目的:

将T1DM的沙特儿童和青少年的认知表现与匹配的对照进行比较.
确定T1DM中血糖控制和认知功能之间的潜在关联.
为减轻儿科T1DM认知缺陷的策略提供信息.

主要方法:

64名参与者的队列 (32名T1DM,32名对照) 根据年龄,性别,种族,教育和BMI进行了匹配.
使用剑桥神经心理测试自动化电池评估的认知功能.
具体测试包括注意力切换任务 (AST) 和选择反应时间 (CRT).

主要成果:

与对照组相比,T1DM患者在AST和CRT参数上表现出显著延迟的认知表现 (p<0.0001).
患有T1DM和HbA1C≥8%的儿童和青少年表现明显差于对照组 (p<0.01).
升高的HbA1C和更长的疾病持续时间与较差的认知功能相关.

结论:

在患有T1DM的儿童和青少年中,认知表现明显延迟.
严格的血糖管理对于预防认知缺陷至关重要.
研究结果支持医疗保健提供者预防微血管并发症和认知障碍.

关键词:

这就是HbA1C.认知功能认知功能在糖尿病中,糖尿病是血糖性糖尿病.第1类糖尿病 1型糖尿病

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