怀孕期间铁状况的纵向评估:在高资源环境中进行前性队列研究
Elaine K McCarthy1, David Schneck2, Saonli Basu3
1Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland; INFANT Research Centre, University College Cork, Cork, Ireland.
The American journal of clinical nutrition
|November 7, 2024
概括
缺铁严重影响孕妇,其患病率在整个妊娠期间都在增加. 建议进行早期查,并将费里的标值达到>60μg/L,以确保足够的铁状况.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 血液学 血液学 血液学
背景情况:
- 铁缺乏症是孕妇全球关注的问题,影响围产期和婴儿健康.
- 关于怀孕期间铁状况的长度研究是有限的.
- 这项研究解决了整个妊娠期间对铁生物标志物的全面分析的需要.
研究的目的:
- 为了评估怀孕期间铁生物标志物的纵向变化.
- 为了确定铁缺乏在初婚妇女的流行率.
- 建立早期怀孕的铁状况切断值来预测第三个月的铁缺乏症.
主要方法:
- 在爱尔兰对629名低风险,原发性孕妇进行前性队列研究.
- 铁生物标志物 (费里丁,sTfR,TBI) 和炎症标志物测量在妊娠15周,20周和33周.
- 在预订时排除患有贫血的妇女.
主要成果:
- 缺铁的患病率 (铁素<15μg/L) 从15周的4.5%上升到33周的51.2%.
- 在15周时,铁素值<60μg/L预测了第三个月的铁缺乏症 (AUC = 0.750).
- 早期补充铁可以降低缺铁风险 (OR:0.57;95% CI:0.390.82).
结论:
- 怀孕显著削弱了母亲的铁状况,即使在补充的人群中.
- 早期怀孕查铁状况至关重要.
- 建议在怀孕早期的目标费里丁度>60μg/L.
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