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牛皮关节炎患者的慢性病:一个队列研究
Fadi Kharouf1,2, Shangyi Gao1, Shahad Al-Matar1,2
1Krembil-Gladman Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
RMD open
|November 7, 2024
概括
慢性病 (CKD) 影响9.2%的牛皮关节炎 (PsA) 患者,风险因素包括糖尿病,结石,关节损伤和NSAID使用. 甲托雷克萨特可能会在PSA中提供保护,防止CKD的发展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 牛皮关节炎 (PsA) 经常与慢性病 (CKD) 相关.
- 了解PsA中CKD的患病率,结果和风险因素对于患者管理至关重要.
- 需要进行前性观察性研究,以阐明PsA患者的长期脏轨迹.
研究的目的:
- 为了确定PsA患者队列中CKD的患病率.
- 描述诊断为CKD的PsA患者的长期结局.
- 确定与PSA中CKD发展相关的风险因素.
主要方法:
- 对PsA患者进行了前性观察队列研究.
- 慢性瘤被定义为至少3个月的估计膜过率 (eGFR) <60mL/min/1.73m2.
- 使用时间依赖的考克斯回归模型来确定CKD发展的风险因素.
主要成果:
- 在1336名PsA患者中,9.2%患有CKD;在随访期间,79.7%患有CKD (中位数为8.2年).
- 慢性病的危险因素包括糖尿病,结石,关节损伤,尿酸升高和每天使用NSAID.
- 甲托雷克萨特使用与慢性病发病风险降低有关 (HR0.51,p=0.01).
结论:
- 在PsA患者中,CKD是显著的并发症.
- 在PsA中CKD的发展与并发症,关节损伤和NSAID使用有关.
- 在PSA群体中,甲索酸可能对CKD有保护作用.
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