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Updated: Jun 8, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
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TMED抑制抑制细胞表面PD-1表达,并克服T细胞功能障碍

David W Vredevoogd1, Georgi Apriamashvili1, Pierre L Levy1

  • 1Department of Molecular oncology and immunology, Netherlands Cancer Institute, Oncode Institute, Amsterdam, The Netherlands.

Journal for immunotherapy of cancer
|November 7, 2024
PubMed
概括

研究人员确定TMED家族蛋白质是CD8 T细胞PD-1表达的关键调节者. 抑制TMED可降低PD-1,增强抗瘤免疫力,并在癌症模型中逆转T细胞功能障碍.

关键词:
收养细胞疗法 - ACT免疫检查点抑制剂 免疫检查点抑制剂免疫治疗是一种免疫疗法.一个T细胞细胞.瘤透淋巴细胞 - - TIL

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