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重复的感官刺激增强和招募感官唤起的皮质人口活动

Leena Eve Williams¹, Laura Küffer², Tanika Bawa^2,3

¹Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland leena.williams@ed.ac.uk anthony.holtmaat@unige.ch.

The Journal of neuroscience : the official journal of the Society for Neuroscience

|November 7, 2024

概括

在清醒的小鼠中,重复性胡须刺激可提高感官皮层神经元活动数小时. 这种感官可塑性可能由促进神经回路变化的特定内部神经元来调节.

科学领域:

神经科学是一个神经科学.
感官处理感官处理
皮层可塑性是指皮层的可塑性.

背景情况:

感官体验和学习与新皮质电路可塑性有关.
在麻醉小鼠中,重复性感官刺激可以诱导长期强化 (LTP).
目前尚不清楚这些变化是否会在清醒期间持续存在.

研究的目的:

为了研究节奏性胡须刺激 (RWS) 对清醒小鼠初级体感皮质 (S1) 神经元活动的影响.
为了确定RWS是否会在清醒期间诱导神经元活动的持续变化.
探索特定的神经元群体,如VIP内部神经元,在感官可塑性中的作用.

主要方法:

在清醒的雄性小鼠的初级体感皮质 (S1) 中,二/三层神经元的时间延迟图像.
在对象采样相关的频率上应用节奏式胡须刺激 (RWS).
分析胡须唤起的神经元活动及其随时间的调制.

主要成果:

在大多数细胞中,RWS诱导了长达1小时的胡须引起的L2/3神经元活动的持续增加.
这种效应是特定于刺激的胡须表现,而不是在遥远的皮层柱中观察到的.
血管活性肠表达 (VIP) 内神经元在RWS期间仅增加了它们的活性,这表明它们在消抑制中发挥了作用.
RWS异质调节神经元活动,在不同的神经元群体中招募或抑制活动.

结论:

在清醒的动物中,重复性感官刺激可以调节皮质神经元对感官输入的表现,持续数小时.
由RWS诱导的感官可塑性可能会通过激活涉及VIP内部神经元的消毒电路而被封闭.
这些发现突出了皮质回路的动态性质,以响应自然主义行为中的感官体验.

关键词:

我们的VIP网络神经元.桶皮质皮质桶皮质没有抑制,没有抑制.长期增强潜力长期增强潜力人体感官皮层 (somatosensory cortex) 是一个感官皮层.突触性可塑性突触性可塑性

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