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Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
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准树突细胞以驱动PDAC免疫疗法反应

Alyssa G Weinstein1, David G DeNardo2

  • 1Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Cancer Biology Graduate Program, Washington University School of Medicine, St Louis, MO 63110, USA.

Trends in pharmacological sciences
|November 7, 2024
PubMed
概括

胰腺癌 (PDAC) 很难用免疫疗法治疗. 一种工程造型的树突细胞疫苗 (DC1) 增加了免疫细胞的透,使PDAC更容易对免疫治疗做出反应.

关键词:
适应性免疫是一种适应性免疫.检查站封锁检查站封锁树突细胞的树突细胞.胰腺癌是一种癌症.胰腺炎是一种炎症.

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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