从奖励消费中划分预期性兴奋:评估可卡因寻求-接受反应链中的固定间隔
Michael Z Leonard1,2, Klaus A Miczek1,3, Herbert E Covington4,5
1Department of Psychology, Tufts University, Medford, MA, USA.
Psychopharmacology
|November 7, 2024
概括
这项研究在老鼠中开发了一种新的链接强化计划,以将寻找药物与服用药物的行为分开. 研究结果显示,这种方法可靠地追踪动机和奖励价值,有助于研究成.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 预期药物可用性强烈激励寻找药物的行为.
- 了解药物自我管理中的食欲和消费过程的神经机制至关重要.
- 需要模型来区分药物使用之前的行为.
研究的目的:
- 隔离和测量奖励采购 (寻求) 和消费 (获取) 行为.
- 为了使这些行为分离,利用一个链接的强化时间表.
- 开发一种用于研究寻找和服用药物的神经基础的工具.
主要方法:
- 雄性Long-Evans老鼠被训练在一个固定间隔/固定比率 (FI-FR) 连锁的时间表.
- 这个时间表将食欲 (寻求) 与消费 (获取) 行为分开.
- 可卡因和糖被用作奖励.
主要成果:
- FI-FR 链条程序有效地将可卡因自我管理分离到寻找和摄取组件.
- 在FI (寻求) 组件中响应反映了预期奖励的激励价值.
- 响应率与预期的奖励大小,和和动机状态相关联.
结论:
- 信息流动组件作为动机变化的敏感度量.
- 它可靠地对激励价值和内部动机状态 (和/剥夺) 的变化进行索引.
- 这种程序对于隔离寻找药物和吸毒行为的神经动态非常有价值.
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