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在青春期内源性和与大麻使用相关的精神病类似经历中对代谢学进行探索性研究

Karoliina Kurkinen¹, Olli Kärkkäinen², Soili M Lehto^3,4,5

¹Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1, FI-70210, Kuopio, Finland. karoliina.kurkinen@uef.fi.

Translational psychiatry

|November 7, 2024

概括

青少年精神病类似经历 (PLE) 与特定的代谢变化有关. 幻觉可能涉及炎症,而大麻使用表明这些体验中能量代谢发生了变化.

科学领域:

神经科学是一个神经科学.
代谢学代谢学代谢学
青少年精神病学青少年精神病学

背景情况:

青春期的精神病类似经历 (PLE) 可以预示早期精神病.
代谢学提供了一个精确的方法来预测精神病.
了解与PLE相关的代谢概况对于早期干预至关重要.

研究的目的:

在抑郁的青少年中调查与PLE相关的代谢变化.
为了确定与不同PLE尺寸相关的特定代谢物.
探索大麻使用对这些协会的影响.

主要方法:

92种化合物的血清代谢物度使用液态染色体质谱分析.
使用青年体验和健康 (YEAH) 调查问卷来评估PLE及其维度.
使用线性回归模型分析了PLE尺寸和代谢物水平之间的关联,并根据包括大麻使用在内的共变量进行调整.

主要成果:

PLE症状尺寸与代谢组呈现一致的相关性,除非调整为大麻使用.
幻觉维度最初与13种代谢物有关.
在对大麻使用进行调整后,发现有8种不同的代谢物与幻觉有关,这表明有不同的途径.

结论:

不同的生物机制是青少年PLE的基础.
幻觉体验可能与炎症过程有关.
大麻使用似乎涉及其他代谢途径,可能增加PLE中的能量需求和生成.

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