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Updated: Jun 8, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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通过K494修改RE-1沉默转录因子的SIRT6依赖功能开关

Adam Zaretsky1,2, Alfredo Garcia Venzor1,2, Ekaterina Eremenko1,2

  • 1Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, 8410501, Israel.

Cell death & disease
|November 7, 2024
PubMed
概括

依赖NAD的脱乙酶SIRT6调节RE-1沉默转录因子 (REST) 的活性. 失去SIRT6会导致REST变得有毒,影响神经元基因表达,并导致神经退行.

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