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Updated: Jun 8, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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抑制FLT3信号抑制可消除阿片类药物耐受性和过敏症,同时保持疼痛缓解

Antoine Jouvenel1,2, Adrien Tassou1,2, Maxime Thouaye1,2

  • 1Université de Montpellier, Montpellier, France.

Nature communications
|November 7, 2024
PubMed
概括

在外围神经元中准fms类铁氨酸激酶受体3 (FLT3) 可以预防阿片类耐受性和过敏症. 将吗啡与FLT3抑制剂结合起来可以增强镇痛,减少副作用,提供更安全的慢性疼痛管理.

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