循环中的短链脂肪酸与中国老年人血压之间的联系
Jiamou Zhou1, Heqiao Zhang1, Pengcheng Huo1
1School of Health Management, Anhui Province, Anhui Medical University, Hefei, People's Republic of China.
Scientific reports
|November 7, 2024
概括
某些短链脂肪酸 (SCFA) 的血清水平与中国老年人的血压有关. 乙酸 (AA) 和酸 (VA) 显示出降低高血压风险的潜力.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 肠道微生物组通过食纤维发酵产生短链脂肪酸 (SCFA).
- 以前的研究表明SCFA和血压之间存在联系,但老年人群的数据很少.
研究的目的:
- 调查中国老年人血清SCFA水平与血压之间的关联.
- 确定可能影响高血压风险和血压读数的特定SCFA.
主要方法:
- 这是一项涉及1013名60岁以上中国成年人的横截面研究.
- 使用UHPLC-QE-Orbitrap MS量化了血清中的SCFA水平 (包括酸,酸,黄油酸,异黄油酸,酸,异酸和酸).
- 统计分析包括多重逻辑回归,线性回归和贝叶斯核-机器回归 (BKMR).
主要成果:
- 乙酸 (AA) 和酸 (VA) 与高血压有负面关联.
- AA与静脉血压 (SBP) 呈负相关性,而异酸 (iso-VA) 与静脉血压 (DBP) 呈负相关性.
- 卡普罗酸 (CA) 与SBP和DBP都有积极的关联. BKMR模型证实了SCFA混合物和高血压/SBP的逆趋势,AA和iso-VA显示负相关性,CA显示正相关性.
结论:
- 血清SCFA概况与中国老年人的血压有关.
- 特定的SCFA如AA和VA可能在高血压管理中发挥作用.
- 针对SCFA,特别是AA,可能为血压干预提供一种新的方法.
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