在美国成年人中,相对脂肪质量和结石之间的关联
Heng Liu1, Mingchu Jin1, Haidong Hao1
1Department of Urology, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, People's Republic of China.
Scientific reports
|November 7, 2024
概括
这项研究发现,更高的腰与身高比率 (RFM) 与结石风险增加有关,高密度脂蛋白胆固醇 (HDL-C) 起着关键的调解作用. 在预测结石方面,RFM显示出比BMI更好的诊断准确度.
科学领域:
- 代谢健康和脏病学
- 流行病学和公共卫生.
背景情况:
- 结石是一个重要的健康问题,有多因素的原因.
- 人类测量措施的作用,如腰与身高的比 (RFM) 在结石的发展需要进一步阐明.
- 高密度脂蛋白胆固醇 (HDL-C) 是已知的心血管风险因素,但其与结石的关联以及潜在的调解作用不太了解.
研究的目的:
- 为了调查RFM和结石之间的关联.
- 为了检查HDL-C在RFM-结石关系中的调解作用.
- 为了比较RFM的诊断准确性与结石的传统措施.
主要方法:
- 对NHANES数据 (2007-2018) 的横截面分析,涉及29712名参与者.
- 采用多变量逻辑回归,子组分析,通用增量建模 (GAM),光滑曲线拟合,ROC曲线分析和调解分析.
- 通过将RFM分类为正常和高分组,进行了敏感性分析.
主要成果:
- 在RFM和结石之间观察到一个积极的关联 (OR=1.41 per SD增量).
- RFM显示了与结石患病率的非线性,正相关性,在年轻人中特别强烈.
- HDL-C调解了RFM-结石关联的13.52%,并且与结石负相关. 与BMI和腰围相比,RFM显示出更高的诊断准确性 (AUC=0.616).
结论:
- RFM独立地与结石风险增加有关.
- HDL-C显著调解了RFM和结石之间的关系.
- RFM作为结石的潜在有价值的诊断标志物,表现优于传统的人类指数.
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