在日本成年人中,脂质积累产品与糖尿病风险之间的非线性关系
Fubing Zha1, Miaoling Chen1, Linlin Shan1
1Department of Rehabilitation, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, No.3002, Sungang West Road, Futian District, Shenzhen, 518000, Guangdong Province, China.
脂质积累产物 (LAP) 与男性和女性糖尿病 (DM) 风险增加有关,观察到性别特定的非线性关联. 降低LAP可能有助于预防糖尿病.
科学领域:
- 代谢健康 代谢健康
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 脂质积累产物 (LAP) 是一种新的,特定于性别的脂质积累指标.
- 以前的研究探讨了LAP-糖尿病的联系,但往往忽视了性别特异性差异.
- 了解这些差异对于有针对性的糖尿病预防战略至关重要.
研究的目的:
- 调查LAP与患上糖尿病 (DM) 的风险之间存在的潜在性别差异.
- 在日本人口中分析LAP和事件DM之间的非线性关系.
- 为了确定与DM风险相关的LAP的性别特定的拐点.
主要方法:
- 从2004年到2015年,对15,263名没有DM的日本个人进行了随访.
- 用立方函数的考克斯比例危险回归模型来分析LAP和事件DM风险.
- 进行了子组和灵敏度分析,以确保研究结果的可靠性.
主要成果:
- 在对共变量进行调整后,女性 (HR:1.02) 和男性 (HR:1.01) 均证实了LAP和DM风险之间的积极关联.
- 确定了非线性关联,女性的 LAP 为 16.58,男性的 LAP 为 11.11.
- 危险比率表明女性和男性的风险增加超出了这些拐点,男性的保护作用低于拐点.
结论:
- 升高的LAP水平与发生性DM的风险增加有关,以性别特定的非线性方式.
- 保持较低的LAP水平,特别是低于已识别的拐点,可能是预防糖尿病的关键策略.
- 这些发现强调了在代谢健康和糖尿病风险评估中考虑性别特异因素的重要性.
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