出生特征和结直肠癌的风险
Jianwen Chen1, Xu Ren2, Yalan Wang1
1Department of Nursing, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, SunYat-sen University Cancer Center, Dongfengdong Road, Guangzhou, 510060, Guangdong Province, China.
BMC gastroenterology
|November 7, 2024
概括
像异常长度和胎盘体重这样的出生特征可能表明胎儿生长受限,这可能是成人结直肠癌 (CRC) 的潜在危险因素. 需要进一步的研究来证实这些关联.
科学领域:
- 流行病学 流行病学
- 围产期健康 围产期健康
- 在瘤学瘤学.
背景情况:
- 新生儿特征与成人结直肠癌 (CRC) 之间的关系仍在争论中.
- 现有的研究缺乏关于这种关联的确证据.
研究的目的:
- 系统地审查和元分析出生特征对成人结直肠癌 (CRC) 发病率的影响.
- 阐明出生特征与晚年CRC风险之间的有争议的关联.
主要方法:
- 在PubMed,Web of Science,EBSCO和Medline数据库中进行全面的文献搜索,截至2024年2月.
- 包括1065篇文章,并提取数据用于系统审查和元分析.
- 分析了来自不同地理区域的十项研究.
主要成果:
- 与正常体重相比,在高或低出生体重的婴儿中没有观察到成人CRC患病率的显著增加.
- 每增加1公斤的出生体重 (95% CI:-1-8%) 时,成人CRC的发病率增加3%.
- 对于男婴来说,较短的身体长度和较轻的胎盘体重被确定为结直肠癌的风险因素,这表明胎儿生长受限.
结论:
- 异常的出生长度,胎盘体重和母亲的年龄可能表明胎儿生长受限.
- 胎儿生长限制与成人结直肠癌 (CRC) 的发病率增加有关.
- 建议进行进一步的流行病学研究以验证这些发现并探索其他出生特征.
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