更年期年龄与2型糖尿病之间的关联:系统性审查和元分析
Mansoureh Yazdkhasti1, Kyana Jafarabady2, Arman Shafiee3
1Reproductive Health Department, Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Nutrition & metabolism
|November 8, 2024
概括
早期和晚期更年期都会增加2型糖尿病 (T2DM) 的风险. 这一系统审查和元分析证实了更年期时间和T2DM发展之间的关联.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
- 更年期开始的时间越来越被认为是慢性疾病的潜在风险因素.
- 现有研究表明,早期或晚期更年期与T2DM之间存在相关性,需要进一步调查.
研究的目的:
- 系统地审查和分析现有关于更年期开始年龄和T2DM之间的关联的研究.
- 与正常的绝经年龄相比,量化与早期或晚期绝经相关的T2DM风险.
主要方法:
- 在包括PubMed,Web of Science,Scopus,Science Direct,Google Scholar和Cochrane在内的主要数据库中进行全面的文献搜索.
- 包括19项研究 (8个队列,11个横截面) 评估T2DM和更年期年龄之间的关系.
- 使用调整的几率比率 (OR) 和危险比率 (HR) 进行对效果大小的聚合分析,使用95%的置信区间 (CI).
主要成果:
- 在早期更年期和T2DM增加的几率之间发现了统计学意义上的关联 (OR = 1.24,95% CI: 1.09-1.40).
- 晚期更年期也与T2DM的几率增加显著相关 (OR = 1.14,95% CI: 1.03-1.26).
- 早期更年期显示T2DM发展的风险明显更高 (HR = 1.31,95% CI: 1.05-1.64),而晚期更年期在风险方面没有显著的关联.
结论:
- 早期和晚期更年期的出现都与患2型糖尿病的风险增加有关.
- 这些发现强调了在T2DM风险评估中考虑更年期时间的重要性.
- 建议进行进一步的研究来证实这些关联并探索潜在的机制.
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