红酵母大米还是洛瓦斯塔丁? 通过多方面的方法对安全性和有效性的比较评估
Giovanna Rigillo1, Giulia Baini2, Renato Bruni3
1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Phytotherapy research : PTR
|November 8, 2024
概括
红酵母大米 (RYR) 显示出作为一种安全的降胆固醇替代药物的潜力. 它的植物复合物提供优越的HMG-CoA减少酶抑制和减少肌肉细胞的影响相比lovastatin.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 生物化学 生物化学
背景情况:
- 红酵米 (RYR) 是一种流行的天然补充剂,用于控制胆固醇.
- 它的有效性归因于莫纳科林K (MK),与洛瓦斯塔丁 (LOV) 完全相同.
- 与纯化他类药物相比,对RYR的安全性和有效性存在担忧.
研究的目的:
- 评估RYR样本与LOV的植物化学成分,药理作用和安全性.
- 为了比较HMG-CoA减少酶抑制活性和RYR和LOV的细胞毒性.
- 为了研究RYR对肌肉细胞基因表达与损伤有关的影响.
主要方法:
- HPLC-DAD用于量化RYR中的莫纳科林和其他生物活性化合物.
- 对HMG-CoA减少酶抑制的酶定量.
- 在体外模拟消化,在模型制造药理动力学.
- 在各种细胞模型中进行体外细胞毒性测定.
- 对肌肉损伤相关的基因表达进行qRT-PCR.
主要成果:
- 在RYR植物化学成分的显著变化,包括二次莫纳可林,三烯和多.
- RYR植物复合物表现出优越的HMG-CoA减少酶抑制与孤立的LOV相比,表明了协同效应.
- 与LOV相比,RYR样本的细胞毒性和对肌肉细胞的影响较低.
- 转录分析表明,对RYR.的肌肉损伤途径的影响减少了.
结论:
- RYR植物复合物可能提供协同降胆固醇效应.
- RYR提供了一个潜在的更安全的替代品,以减少肌肉毒性净化他类药物.
- 需要进一步的研究来证实临床疗效和阐明协同作用机制.
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