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Updated: Jun 8, 2025

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Published on: February 27, 2020

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增强有效载荷定位在抗体-药物结合物中,使用中向下质谱方法与质子转移电荷减少

Linda B Lieu1, Cynthia Nagy2, Jingjing Huang3

  • 1University of Oklahoma, Department of Chemistry and Biochemistry, 101 Stephenson Parkway, Norman, Oklahoma 73109, United States.

Analytical chemistry
|November 8, 2024
PubMed
概括

中向下质谱法 (MD MS) 与质子转移电荷减小法 (PTCR) 简化了抗体-药物合物 (ADC) 分析. 这种先进的技术精确地绘制了复杂ADC分子上的药物结合部位.

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