将两种过渡策略与帕利皮里棕酸盐进行比较 - 每6个月一次
Christoph U Correll1,2,3,4, Karen L Johnston5, Ibrahim Turkoz6
1Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA.
CNS spectrums
|November 8, 2024
概括
帕利皮里棕酸每6个月一次 (PP6M) 的注射显示,从每月一次 (PP1M) 或每3个月一次 (PP3M) 的注射过渡到精神分裂症的成年人中复发率较低. 在过渡组之间,效率和安全性是可比的.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 之前的一项非劣势性试验证实了每6个月一次 (PP6M) 的帕利佩里对每3个月一次 (PP3M) 的帕利佩里的非劣势性,用于预防精神分裂症复发.
- 这次特此后分析专门评估了从PP1M或PP3M向PP6M过渡的患者的疗效和安全性.
研究的目的:
- 评估成年精神分裂症患者从PP1M转向PP6M的疗效和安全性,而不是PP3M.
- 为了比较这两个过渡途径之间的复发率,症状严重程度,功能和不良事件.
主要方法:
- 一个为期12个月的双盲随机试验,涉及患有精神分裂症的临床稳定成年人.
- 接受PP1M或PP3M的患者被随机分为1:2接受PP3M或PP6M.
- 主要终点是复发的时间;次要终点包括PANSS,CGI-S和PSP得分以及安全性评估.
主要成果:
- 在两个过渡组中观察到低复发率 (PP1M到PP6M:7.8%;PP3M到PP6M:7.3%).
- 在两组之间的PANSS,CGI-S或PSP得分变化中没有发现显著差异.
- 治疗出现的不良事件 (TEAE) 的发生率相似 (61.0%对63.2%).
结论:
- 从PP1M或PP3M过渡到PP6M,导致精神分裂症成年人的复发率相对较低.
- 症状控制,功能结果和安全概况在两个过渡途径中都是一致的,支持PP6M作为一个可行的选择.
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