甲状腺功能低下症预测了救援口腔切除术后的发展
Andrew D P Prince1, Zachary M Huttinger2, Molly E Heft-Neal1
1Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
概括
手术后的甲状腺功能低下症显著增加了口腔皮瘤发育和救援口腔瘤切除术后重新手术的风险. 治疗甲状腺功能低下症可能会减少这些伤口并发症.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术瘤学手术瘤学
- 内分泌学 在内分泌学.
背景情况:
- 以前的研究将术后的甲状腺功能低下与在救援喉腔切除术中伤口愈合不良联系在一起.
- 没有研究在救援口腔切除术患者中调查过这种关联.
研究的目的:
- 为了检查术后甲状腺功能低下症和口腔皮囊发育之间的关系.
- 为了识别与相关的因素,需要在救援口腔大切除术后重新进行手术.
主要方法:
- 对53名因复发性口腔状细胞癌而接受救援口腔切除术的患者进行了回顾性队列研究.
- 手术后的甲状腺功能低下症定义为甲状腺刺激激素 (TSH) > 5.5 mIU/L.
- 多变量分析以评估与甲状腺功能低下症相关的风险.
主要成果:
- 37.7%的患者患有术后甲状腺功能低下症.
- 甲状腺功能低下症患者的状腺发作率明显高 (35%对9.1%,P=.03).
- 甲状腺功能低下症增加了13.6倍 (P=.038) 的状腺复手风险和9.5倍 (P=.013) 的状腺发育风险.
结论:
- 手术后的甲状腺功能低下是状腺发育的预测因素,在抢救口腔切除术后需要进行手术管理.
- 建议在手术后治疗甲状腺功能低下症,以减轻伤口并发症.
- 这一发现强调了甲状腺激素管理在优化手术结果方面的重要性.
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